Adverse environmental conditions in the prenatal period, notably maternal depression, maternal obesity and socio-economic disadvantage, are acknowledged risk factors for later child mental health problems. Biological factors including immune, neurotrophic and metabolic factors have also been related with child mental health problems, but mostly in animal research or in human cross-sectional studies.
The underlying biological pathways relaying the longitudinal effects of early life adversity to child mental health remain mostly unknown. The overarching aim of the project is to identify the biological pathways (immune, neurotrophic, metabolic factors in the cord serum) mediating the effects of adverse prenatal environment on child mental health. The project relies on the two French birth cohort studies EDEN and ELFE, which include comprehensive environmental, biological and behavioral data on children and their parents, from pregnancy to 8 years.
Project funding: 2023-2027 ANR 2023 AAPG PRC
ESSMA Team members involved:
Judith VAN DER WAERDEN, Susana BARBOSA, Sara AVENDANO, Arthur DESCARPENTRY.
Collaborations: C Galéra (PI- Bordeaux Population Health (U1219- HEALTHY), Laetitia DAVIDOVIC (IPMC/ CNRS UMR7275), Barbara Heude (CRESS OPPaLE team)
Our team is located on a single site, on the 3rd floor of the Pierre et Marie Curie Faculty of Medicine, Pôle Saint-Antoine
27 rue de Chaligny
Paris 12°
Tél.: +(33) 01.44.73.84.45
Métro : Faidherbe-Chaligny (8), Reuilly Diderot (1)
Bus : 46 – 86
Vélib : Station 1108, 223 rue du Faubourg Saint-Antoine
